No it should not. Particularly if you are using that term as your h1 (which doesn't have huge ranking influence). Your h1 should have keywords and should be relevant for the user -- generally it is one of the first things a visitor will see when landing on your page. You want your page and h1 to be relevant and readable for the visitor.
The Google algo is developed enough that it will understand prepositions, conjunctions in proper context. So if it makes sense to use "in" for the context of the page then use it, if not don't.
